Biomolecular Sensors for Decentralized

Point-of-Need Infectious Disease Diagnosis
mercredi, 30 septembre 2020 - 11:30 am
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Who: Prof. Shana Kelley, Department of Biochemistry, University of Toronto, 144 College St., Toronto, Ontario M5S 3M2, Canada

When: September 30, 2020 at 11:30 am

Where: Zoom. Request the link by email.

Abstract

To put disease-related biomarkers to work in the clinic, new high-performance technologies are needed to enable rapid and sensitive analysis of clinical specimens. Electrochemical methods providing low cost and direct biomarker readout have attracted a great deal of attention for this application. We exploit controlled nanostructuring of electrode surfaces to enhance biomolecular capture rates and efficiencies to solve this long-standing problem, and showed that the nanoscale morphologies of electrode surfaces control their sensitivities. An electrocatalytic reporter system that leverages a pair of redox reagents is used to readout the presence of specific nucleic acids and other analytes bound to electrode surfaces. Recently, we have developed assays that are able to detect nucleic acids, proteins and small molecules, with universally high sensitivity levels. This presentation will highlight how these nanostructured sensors can be applied to the development of automated testing systems for infectious disease diagnosis and the rapid assessment of viral infection.