Department of Chemistry and Biomolecular Sciences Colloquium

Presented by Professor Andreea R. Schmitzer
Wednesday, 17 October 2018 - 11:30 am to 1:00 pm
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(613) 562-5728
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Free of charge
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The Department is pleased to welcome Professor Schmitzer from University of Montreal.

Join us at 11:10 for refreshments followed by her lecture "Synthetic ion transporters: from fundamental studies to promising biological applications"

ABSTRACT: All cell types have chloride channels and carriers in their plasma membranes as well as in each of the subcellular membrane organdies including the nuclear membrane, endoplasmic reticulum, Golgi apparatus, lysosomes, endosomes, and mitochondria. Chloride is the most abundant anion in the extracellular environment of different organisms. Its transport across cellular membranes contributes to diverse physiological processes. In the last few years, our group devoted particular attention to the development of synthetic ion transporters that show promising activity in model systems, such as liposomes. More recently, we have begun to consider the potential of using synthetic anion ionophores for biological applications, applications that will be discussed in this presentation. Pursuing the development of supramolecular systems to assist anion transport, we developed new families of organic cationic transporters that act as anion carriers. In stark contrast to the modulation of the activity of anion channels, nature has provided only few examples of processes that modulate chloride carriers. Perhaps also for historical reasons anion channels have commanded greater attention than have chloride carriers. We will also discuss the aspects and strategies to modulate the biological activity of these synthetic anionophores in complex environments.