Special Lecture

Integrative Molecular Epidemiology of Ovarian Cancer
Friday, 5 May 2017 - 12:00 pm to 1:00 pm
Location
Room number: 
LPR 284
Registration
Registration required: 
No
Cost to attend: 
Free of charge
Event language: 

 

SPEAKER: Dr. Ellen Goode, Professor of Epidemiology, (Health Sciences Research, Mayo Clinic)             ABSTRACT: Research Area: Statistical Genetics Seminar Series Name: STAGE International Speaker Series (videoconference) Epithelial ovarian cancer is a signi cant cause of women’s gynecologic morbidity and mortality. It comprises ve histotypes (high-grade serous, endometrial, clear cell, mucinous, low-grade serous) which arise from distinct pre-neoplastic lesions with varied somatic mutation spectrums. While high-penetrance genes (e.g., BRCA1, BRCA2, MLH1, MSH2) are known to contribute to risk, the residual risk associated with family history that is attributable other particular inherited factors remains to be re ned. Genome-wide association studies (GWAS) within large consortia have identi ed more than thirty common variants associated with modest risk of this disease. This seminar will provide an overview of the methods and results from these studies, including the customized, genome-wide Illumina OncoArray panel. Another major advance of recent years is the detailed characterization of case subsets. In particular, tumor immunophenotyping, molecular subtyping, and DNA methylation pro ling show promise for characterization of high-grade serous disease. As clinically relevant phenotypes may also be predicted by the genomic features of epithelial ovarian cancers, ideas for novel investigation will also be explored which demonstrate the potential of integrating tumor and germline features. In sum, recent progress in the molecular and genetic epidemiology of epithelial ovarian cancer can serve as a framework for integrative studies of